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The end replication problem hypothesis proposes that the ends of linear DNA cannot be ..... replication (34). To know if the end replication problem occurs ...

http://mcb.asm.org/cgi/reprint/21/17/5753.pdf

solve the end replication problem. Carolyn M Price*. Department of Cancer and Cell Biology, University of Cincinnati, Cincinnati, OH, USA ...

http://www.nature.com/emboj/journal/v28/n7/pdf/emboj200964a.pdf

has found numerous solutions to the end- replication problem that serve ... Telomerase solves the end-replication problem in many eukaryotes by adding ...

http://www.nature.com/nsmb/journal/v15/n1/pdf/nsmb0108-18.pdf

The end replication problem. -during lagging strand replication a primase creates RNA/DNA hybrids to which DNA polymerase α binds and extends to form ...

http://www.biology.ualberta.ca/courses.hp/gen301.hp/Lecture 13.pdf

by J Nosek - 2004 - Cited by 1

http://www.zsf.jcu.cz/jab/2_2/nosek.pdf

by MZ Levy - 1992 - Cited by 493

http://www.elsevier.com/framework_aboutus/pdfs/Telomere-end-replication-problem-and-cell-aging_1992_Journal-of-Molecular-Biology.pdf

Many linear genomes. The difference between continuous and semi-discontinuous replication ... The End Replication Problem; The Special Dilemma ...

http://www.faculty.biol.ttu.edu/densmore/MB06pdfs/Molecular lect 10.06.pdf

Semi-conservative replication. Biochemistry of replication. End replication problem. DNA mutation and repair. *Transcription ...

http://courses.biology.utah.edu/kropf/cell/lecture_PDFs/L10.pdf

DNA is replicated incompletely because of end-replication problem (see ... End-replication problem happens in the duplication of linear DNA. ...

http://2009.igem.org/files/poster/Kyoto.pdf

This end replication problem predicts the progressive loss of telomeric DNA in the absence of a mechanism to overcome this process (1, 2). ...

http://cancerres.aacrjournals.org/cgi/reprint/56/7/1503.pdf

Explain briefly how telomerase solves the end replication problem. ... If telomerase stays active, the end replication problem is solved and chromosomes ...

http://biology.ucsd.edu/classes/old.web.classes/bimm100.FA04/other/pbset2.pdf

The End Replication Problem. RNA primer removal. RNA5'. 3' parent daughter. 5'. 3' parent daughter. DNA would progressively shorten! end of chromosome ...

http://biology.ucsd.edu/classes/bggn220.FA07/10_1_07p PASQ Replication.pdf

Eukaryotic DNA Replication. 1) Comparison with bacterial DNA replication. 2)Reverse transcription. 3)The end replication problem. Telomeres and telomerase ...

http://voh.chem.ucla.edu/vohtar/spring05/classes/153B-1/pdf/lecture15a.pdf

'end-replication' problem [7,8]. Recent high-resolution ana- lysis of telomere dynamics has revealed allelic variation in telomere length that segregates ...

http://www.biochemsoctrans.org/bst/034/0581/0340581.pdf

the end replication problem, eukaryotic cells require a mecha- .... FIGURE 1. The end replication problem and telomerase. A, end replication problem. ...

http://www.jbc.org/content/284/24/16061.full.pdf

However, oxidative stress exerts major influence on telomere shortening over and above that of the end-replication problem because, evidently, ...

http://pt.wkhealth.com/pt/re/medcare/fulltext.00004268-200904000-00004.pdf

These findings underscore the complexity of leukocyte telomere dynamics in vivo and suggest that determinants in addition to the “end-replication problem” ...

http://pt.wkhealth.com/pt/re/merck/fulltext.00000429-200902010-00009.pdf

by CW Greider - 1998 - Cited by 86

http://bret.mc.vanderbilt.edu/igp/html/Cell_Division_02/Greider_98.pdf

by the end replication problem is demonstrable in dogs from a number of different breeds and to evaluate whether interbreed differences exist in TRFs. ...

http://jn.nutrition.org/cgi/reprint/132/6/1604S.pdf

the end-replication problem but ensured the presence of the same sequence at all chromosome ends. Once all telomeres in the cell had the same ...

http://www.sciencemag.org/cgi/reprint/326/5955/948.pdf

and above that of the end-replication problem because, evidently, the GGG triplets on the telomeres are highly sensitive to the hydroxyl radical. ...

http://hyper.ahajournals.org/cgi/reprint/HYPERTENSIONAHA.109.128926v1.pdf

Telomeres and the end replication problem. Telomerase: a ribonucleoprotein (RNA and protein) reverse transcriptase. 1. Its RNA has sequence complementary to ...

http://www.sci.uidaho.edu/biosci/labs/wichman/courses/Biology 210/2006/Macs/Exam 3mac/Lec19and20ReplicateRecomb.pdf

How do these viruses overcome the 5'-end replication problem? ... why do they need terminal repeats, and how do they overcome the end-replication problem?

http://robles.callutheran.edu/~revie/virology/Virology-Review-1-2009.pdf

The end-replication problem. Telemeres shortened with each cell division because DNA polymerases cannot fully replicate 3' termini; ...

http://science.nctu.edu.tw/degree/newsd/file/Lecture 6 on DNA and replication.pdf

DNA end replication problem, whereby telo- meres shorten with each subsequent cell division. When a critical telomere length is reached cells ...

http://www.springerlink.com/index/YK5Q14U374203113.pdf

owing to the "end replication problem" diminishes the protective capacity of the telomeres, leading to increased chromosomal degradation or fusion during ...

http://www.springerlink.com/index/J75770420456859K.pdf

can solve the end replication problem because it is a specialized reverse tran- scriptase that is independent of preex- isting parental DNA templates. In- ...

http://infoscience.epfl.ch/record/114175/files/Lingner J_BSC 1998.pdf

replication problem' (Fig. 1). The effect of the end replication ... Schematic illustration of the end replication problem. Somewhere along the 3′ terminus ...

http://jcs.biologists.org/cgi/reprint/108/1/1.pdf

This quandary, known as the end- replication problem, was elegantly resolved by the discoveries for which this year's Nobel Prize is awarded. ...

http://nobelprize.org/nobel_prizes/medicine/laureates/2009/public_en.pdf

Replication problems at the ends of the DNA strand. 11. Telomerase solves the end-replication problem. 12. Using PCR to clone telomerase RNA genes ...

http://www.hhmi.org/biointeractive/rna/double_life_of_RNA_DVD_chapter_list.pdf

end-replication problem. In most eukaryotes, the telomerase enzyme directs the synthesis of new telomeres; this process is described in more detail ...

http://www.informaworld.com/index/792231405.pdf

END-REPLICATION PROBLEM. DNA polymerase in higher organisms does not initiate the synthesis of a new DNA strand. Rather it extends an exist- ...

http://www.informaworld.com/index/790498510.pdf

the end-replication problem, the accompanying loss of binding sites for Taz1 (or mammalian TRF1/TRF2) may lead. 26. London Research Institute Scientific ...

http://science.cancerresearchuk.org/reps/pdfs/lrireportsections2007/cooper.pdf?version=1

by M Balasubramanyam - 2004 - Cited by 1

http://www.ias.ac.in/currsci/aug252004/422.pdf

different? •How are origins of replication prevented from firing more than once? •How does telomerase solve the chromosome end problem in eukaryotes? ...

http://www.neurofly.com/molBio_files/DNA Replication II.pdf

by JL Osterhage - 2009 - Cited by 6

http://www.lib.gdpu.edu.cn/cyzy/tssjk/lbeyxjzt/2009lbejzt/yjjz/200912/P020091207392460313509.pdf

solves the end-replication problem by elongating telomeres to counteract end shortening. Classic Experiment. Immortalizing Human Cells with Telomerase ...

http://www4.utsouthwestern.edu/cellbio/shay-wright/publications/classic.experiment.pdf

Every time the cell divides, telomeric repeats are lost due to the “end-replication problem” that was first predicted by James Watson6 and Alexei ...

http://www4.utsouthwestern.edu/cellbio/shay-wright/publications/Cell Cycle 4.e108.2005 Sfeir Fine-tuning End Nucleotide.pdf

18 Jan 2010 ... ase cannot fully replicate the 3! end of linear DNA during mitosis, the so- called end replication problem (fig 1), ...

http://heart.bmj.com/content/94/5/537.full.pdf

7. What is the eukaryotic chromosome end replication problem? How the problem was naturally resolved? (10 points). (1) The lagging strands of the eukaryotic ...

http://202.114.65.51/fzjx/fzswx/zyyks/lcksstjda/2006/2006quiz1.pdf

19 Sep 2006 ... End-replication problem-telomere loss in cell division. Lost at a rate of 40 - 200 bp per cell division. McKenzie et al., 1999 ...

http://videocast.nih.gov/pdf/dnarig091906.pdf

1 Jan 2008 ... has found numerous solutions to the end- replication problem ... Telomerase solves the end-replication problem in many eukaryotes by adding ...

http://ribonode.ucsc.edu/Pubs/AresChakrabarti08.pdf

structure, called “the end replication problem”.4 The understanding at the time was that DNA polymerase, the enzyme responsible for the replication of the ...

http://www.cuny.edu/research/sr/nobel-science-challenge/2009NobelFinal.pdf

4 Dec 2008 ... leukocyte telomere dynamics in vivo and suggest that determinants in addition to the ''end-replication problem'' ...

http://aje.oxfordjournals.org/cgi/reprint/kwn338v1.pdf

Bacteria do not have the end-replication problem, because their DNA is circular. In eukaryotes, chromosomal DNA is linear: each chromosome has two ends, ...

http://isites.harvard.edu/fs/docs/icb.topic597218.files/BIOS E-18 Pre-Reqs.pdf

by R Stindl - 2004 - Cited by 15

http://www.stindl.info/pdfs/Stindl2004.pdf

The end-replication problem. Telomeres. DNA polymerase activity. •Polymerization. •3'> 5'exonuclease activity. •5'> 3'exonuclease activity ...

http://www.cgu.edu.tw/mip/phd/chiou/細生/DNA replication and repair.pdf

The “End Replication” Problem. ∎ The mechanism of DNA replication was investigated. ∎ The mechanism of DNA replication was investigated and elucidated ...

http://www.aamc.org/research/adhocgp/030510berg.pdf

Topoisomerases temporarily break the DNA molecules so the stands can separate. ✳ Linear DNA molecules use telomerase to solve the “end replication problem” ...

http://www.as.ysu.edu/~crcooper/3702Ch11(F07).pdf

What is the end replication problem? How do cells solve it? (20%). 3. What is the function of ORC and Mcm hexamer during DNA replication? (20%) ...

http://moodle.ncnu.edu.tw/file.php/9919/細生第四章-DNA_replication_repair_and_recombination.pdf