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tulated mechanism of action of HOE 077, a conceptual problem remained ... gen. 2,8-10 Therefore, if HOE 077 were to modulate stel- late cell fibrogenesis by the ...

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376. I. Sakaida et al.: HOE 077 blocks TIMP-1 in rat liver fibrosis. J Gastroenterol 1999; 34:376–377. Short communication. Prolyl 4-hydroxylase inhibitor (HOE ...

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HOE 077, a prolyl 4-hydroxylase inhibitor, is a poten- tial antifibrotic agent. In the choline-deficient l-amino acid diet rat model of cirrhosis and HCC, HOE 077 ...

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nal epithelia that utilize the same system of repair, how- .... How are these regu- lated? Soluble ..... hydroxylase inhibitor HOE 077 prevents activation of Ito cells, ...

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K. Prolyl 4-hydroxylase inhibitor (HOE 077) inhibits pig serum- induced rat liver fibrosis by preventing stellate cell activation. J Hepatol 1997;27:185–92. 15.

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Okita K: Prolyl 4-hydroxylase inhibitor (HOE 077) inhibits pig serum-induced rat liver fibrosis by preventing stellate cell ac- tivation. J Hepatol 27:185–192, 1997 ...

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(HOE 077), to rats fed a CDAA diet reduced this increase in liver ... HOE 077 prevents liver fibrosis even in male Wistar rats and evaluated its effect on the extent ...

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Anti-fibrotic HOE 077 has recently been investigated to limit fibrosis in pancreatic islets (66). Originally a treatment for liver fibrosis, initial results suggest that the ...

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May 28, 2011 ... 4-hydroxylase, HOE 077, which would be converted to the active form by ... studies reported that HOE 077 prevented activation of. HSCs as ...

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Feb 26, 2004 ... Okita K. Prolyl 4-hydroxylase inhibitor (HOE 077) inhibits pig serum-induced rat liver fibrosis by preventing stellate cell activation. J Hepatol ...

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13 Sakaida I, Uchida K, Hironaka K, Okita K. Prolyl 4-hydroxylase inhibitor (HOE 077) prevents TIMP-1 gene expression in rat liver fibrosis. J Gastroenterol 1999 ...

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held in Paris, France, 11-13 June 2001, and published in RTO-MP-077. ... plastic; although conventional displays can be engineered to use HOEs, the broad ...

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The inhibitor HOE-077 has been withdrawn from trials due to the side effects found in dogs.(250). ▪ Inhibition of HSP47. Antisense oligonucleotides prevent ...

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novel antifibrotics, HOE 077 and Safironil, modulate stellate cell activation in rat liver injury: differential effects in males and females. Am J Pathology 1998; 152: ...

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aka K, Okita K. The prolyl 4-hydroxylase inhibitor HOE 077 prevents activation of Ito cells, reducing procollagen gene expression in rat liver fibrosis induced by ...

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279 Two Novel Antifibrotics, HOE 077 and Safironil, Modulate Stellate Cell Activation in Rat Liver Injury: Differential Effects in Males and Females. Yuan-Jen ...

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The prolyl 4-hydroxylase inhibitor HOE 077 prevents activation of Ito cells, reducing procollagen gene expression in rat liver fibrosis induced by choline- deficient ...

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Hepatology 28 1707 1709 1998. 11) Matsumara Y, Sakaida I, Uchida K, Kimura T , Ishihara T,. Okita K. Prolyl 4 hydroxylase inhibitor (HOE 077) inhibits ...

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macokinetics of the prolyl 4-hydroxylase Inhibitor HOE 077 in the first human study. Z. Gastroenteroi. 12, 714. 7. Sher, P. P. (1982) Drug interferences with ...

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HOE 077 pyridine-2,4-dicarboxylic-di-(2-methoxyethyl)amide. HPLC high pressure liquid chromatography. Hyp,O. 4(R)-hydroxY-L-proline. He, I isoleucine ...

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NO+HOe -• NOs +OH .045 .094 .053. 0(03). -.711. -.065. -.714. Odd O x flux ( lower b.c.). -.079. -.055. -.074. OH+O3 '-> HOe +Os. -.065. -.045. -.077 o (NOs) . 083 ...

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Inhibitors of collagen synthesis such as HOE 077, which blocks the enzyme prolyl hydroxylase, were among the first antifibrotic com- pounds tested in liver, but ...

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Clement B, Chesne C, Satie AP, Guillouzo A. Effects of the prolyl 4-hydroxylase proinhibitor hoe-077 on human and rat hepatocytes in primary culture. J. Hepatol ...

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