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bearing on the neurodevelopmental theories of schizo- phrenia (2, 3), especially because .... expression of HLA-B35 in schizophrenia. Psychiatr Genet. 1996; 6:51–59 ... Chabot S, Williams G, Yong VW: Microglial production of TNF- ...

http://ajp.psychiatryonline.org/cgi/reprint/156/11/1725.pdf

also shared by proponents of the neurodevelopmental theory (42)—that schizophrenia is predominantly a disease of young males. .... Kallmann FJ: The genetic theory of schizophrenia: an analy- ... sib-pair scoring methods to detect HLA-linked disease sus- ... poux F, Feingold J, Waksman G, Mallet J: Evidence for a ...

http://ajp.psychiatryonline.org/cgi/reprint/155/10/1365.pdf

infectious theories of schizophrenia waned until the early. 1970s. In 1972, the slow virus diseases of kuru and .... schizophrenia has a neurodevelopmental origin (54, 55), .... might expect specific HLA antigens to be associated with ..... G. Evidence for autoimmune antibodies directed against neural cell adhesion ...

http://www.informaworld.com/index/792540458.pdf

and to the emerging neurodevelopmental theory of schizophrenia. It will demonstrate that it is no ...... detecting HLA-linked genes in disease, Tissue Antigens,. HECKENLIVELY, .... SACCHE~I, E. VITA,A., CALZERONI, A,,INVERNIZZI, G. & ...

http://www.informaworld.com/index/787052942.pdf

neuro-developmental hypothesis of schizophrenia, the other popular ..... 6 Gottesman, I. I. & Shields, J. A polygenic theory of schizophrenia. Proc. ... 21 Todd, J. A., Bell, J. I. & McDevitt, H. O. HLA-DQ beta gene .... 53 Walsh, T., McClellan, J. M., McCarthy, S. E., Addington, A. M., Pierce, S. B., Cooper, G. ...

http://www.nature.com/jhg/journal/v54/n1/pdf/jhg20087a.pdf

by JL SOBELL - 2002 - Cited by 40

http://www.mayoclinicproceedings.com/content/77/10/1068.full.pdf

DA theory of schizophrenia. The importance of this observation for autism is ..... histocompatibility leukocyte antigen (HLA)-G can stimulate mononuclear cells ..... in the offspring: a neurodevelopmental animal model of schizophrenia. ...

http://www.springerlink.com/index/X7W371830R836885.pdf

far, associations of certain HLA-loci with schizophrenia were described (Laumbacher et al. ...... Huber G (1983) Das Konzept substratnaher Basissymptome und seine ... for the theory and therapy of schizophrenic diseases]. Nervenarzt 54: .... Murray RM, Lewis SW (1987) Is schizophrenia a neurodevelopmental disorder? ...

http://www.springerlink.com/index/X1633362U27T182G.pdf

by CR Morris - Cited by 2

http://www.alternative-therapies.com/resources/web_pdfs/recent/0709_morris.pdf

by N Kaminen-AholaVoskul J, Rosen G. D, Galaburda A. M. and LoTurco J. J. 2006: DYX1C1 .... Theories of developmental dyslexia. 1.3.1. The phonological theory ...... functioning of the immune system and developmental dyslexia, such as HLA region on ...... transcript variants, and polymorphism associated with schizophrenia. ...

https://oa.doria.fi/bitstream/handle/10024/4308/suscepti.pdf?sequence=1

by L Lahdelma - 2009The theory suggests that the development of these two diametric ... non-classical HLA class I gene, i.e. HLA-G plays an important role during ...... neurodevelopmental animal model of schizophrenia. Biological Psychiatry ...

https://oa.doria.fi/bitstream/handle/10024/50467/biologic.pdf?sequence=1

by CGS PalmerIn an excellent review of this theory of schizophrenia, ..... another neurodevelopmental disorder, and maternal-fetal HLA matching may occur more ...... Dahlquist, G. and B. Kallen, Maternal-child blood group incompatibility and other ...

http://www.hindawi.com/journals/jbb/aip.576318.pdf

designed to explain the putative neurodevelopmental ori- gin of schizophrenia. .... ble with an association with a gene in the HLA region, but in contrast to the above studies, ..... support for the theory that neurological signs represent a ..... Berrios, G., and Porter, H, eds. A History of Clinical ...

http://schizophreniabulletin.oxfordjournals.org/cgi/reprint/24/4/501.pdf

schizophrenia and HLA haplotypes is controversial and far from clear-cut; .... neural function, mean that they are just as likely as neurotransmitters to ... This theory raises at least two provocative questions: Do other ..... antiserum alters the developmental pattern of T- and B-lymphocytes in ...

http://schizophreniabulletin.oxfordjournals.org/cgi/reprint/17/4/669.pdf

(Ig) G antibodies bound to a bacterial surface as an example of a target. ..... located at the HLA class III region of the human genome (C2, factor B and ..... A. Schizophrenia--neurodevelopmental and neurodegenerative theory revisited. ...

http://journals.prous.com/journals/servlet/xmlxsl/dnp/20082104/pdf/dn210200.pdf?p_JournalId=3&p_refId=4012&p_IsPs=Y

by AL JONES - 2005 - Cited by 39

http://espace.library.uq.edu.au/eserv/UQ:9934/mp_icb_83_05.pdf

by S Prasad - 2002 - Cited by 50

http://www.ias.ac.in/jbiosci/feb2002/35.pdf

Molecular genetics of schizophrenia: past, present and future ... formation, neural networks and the brain-mind relation ... Developmental mechanisms: putting genes in their place .... Role of HLA antigens in Rh(D) alloimmunized pregnant ..... Homberger Dominique G. Steven J Gould – an appreciation ...

http://www.ias.ac.in/jbiosci/dec2002/715.pdf

to be explained by any aetiological theory of schizophrenia, genetic or otherwise, and add a longitudinal aspectto thephenotype. .... between HLA A9 and schizophrenia has been .... 16 Der G, Gupta S, Murray RM. Is schizophrenia disappear- ..... The Neuro- developmental Basis of Schizophrenia. Georgetown: RG ...

http://jnnp.bmj.com/content/60/6/604.full.pdf

HLA DR2 DQ1 with the narcoleptic syn- drome. This association is restricted to ... schizophrenic psychosis. Two-thirds were free .... The session on developmental neuro- ... ment of the theory of mind. Dr G Jackson (London) reported new ...

http://jnnp.bmj.com/cgi/reprint/57/1/122.pdf

by H Nikkilä - 2000 - Related articles

http://ethesis.helsinki.fi/julkaisut/laa/kliin/vk/nikkila/cerebros.pdf

Several theories of schizophrenia are in prevalence; most of ..... developmental perturbations that increase risk for schizophrenia is through partial antagonism of the NMDA ...... in the frontal cortex of schizophrenic patients. J Neural ..... Curran T, D'Arcangelo G. Role of reelin in the control of brain ...

http://medind.nic.in/iaf/t08/i4/iaft08i4p307.pdf

Several aetiological theories have been proposed for schizophrenia, ..... Infectious and immune factors in neurodevelopmental damage. ... 13 Knight J, Knight A, Ungvari G. Can autoimmune mechanisms account for the genetic .... Trucco M, Ganguli R. Negative association of schizophrenia with HLA DQB1*0602: evidence ...

http://pt.wkhealth.com/pt/re/dyslipidaemia/fulltext.00004228-200502000-00002.pdf

by LM Boulanger - 2004 - Cited by 96

http://biology.ucsd.edu/labs/boulanger/NRNS 04.pdf

by DR Hanson - 2005 - Cited by 56

http://www.biomedcentral.com/content/pdf/1471-2350-6-7.pdf

by ALO Hebb - 2008is coupled to the G protein Gαs, which subsequently activates adenylyl cyclase, increasing intracellular cAMP .... thought to play a key role in inciting neurodevelopmental ..... markers (interleukin-2 and HLA-DR) in depression: Further ..... Theories of schizophrenia: A genetic- inflammatory-vascular synthesis. ...

http://www.biomedcentral.com/content/pdf/cd-921655.pdf

the frequency of a specific HLA antigen is increased in patients with reversals but not ...... early developmental disturbance resulting .... theory of schizophrenia that builds upon ear- ..... and neural fund ion Baltimore: Williams and Wilkins, ..... Langfeldt, G. The prognosis in schizophrenia and the ...

http://psycnet.apa.org/journals/bul/94/2/195.pdf

theory of schizophrenic thought disorder. The distractors had greater ... nucleus ansae peduncularis in neuro- psychiatric disease. Archives of ...... compatible with a developmental defect, cresyl violet stained sections ...... In order to determine if HLA-B27 could serve as a genetic marker for ...

http://psycnet.apa.org/journals/szb/10/3/472.pdf

... of psychoanalytic theory in America and disenchantment with the genetic theory in Europe, the genetic or ..... association of schizophrenia with HLA DQB1* 0602 among African- ...... The possibility that schizophrenia is a neurodevelopmental ...... Adams, R.D., Lyons, G. (1982) Neurology of hereditary metabolic ...

http://dspace.ncl.res.in/dspace/bitstream/2048/148/1/th1351.pdf

accepted view that schizophrenia is a neurodevelopmental disorder. ...... whole blood at 800 g for 15 min. 1 ml of packed RBCs was used for quantitation ...... Andreasen, N.C., et al (1998) “Cognitive Dysmetria” as an integrative theory of schizophrenia: A ...... between schizophrenia and the HLA DQB1 gene locus. ...

http://dspace.ncl.res.in/dspace/bitstream/2048/125/1/th1308.pdf

Theories of Schizophrenia Based on Specific Aspects of. CNS Development .... that the combination of early and late developmental ... ophrenic patients that are inversely related to neuro- ... Immunohistochemical identification of HLA class II an- ..... feron-a and -g by leukocytes from patients with schizophrenia. ...

http://pdfs.journals.lww.com/jonmd/1990/12000/Immunopathology_and_Viral_Reactivation__A_General.1.pdf

1967 hypothesis that phenotypic schizophrenia was an expression of ..... abnormality in HLA antibodies. Children with this ge- .... sated, according to the theory, some high-risk longitudi- ... future in utero and/or neonatal neurodevelopmental, .... G, Levin S, Lange K, Levy D (1988) A single dominant gene can ...

http://pdfs.journals.lww.com/jonmd/1993/05000/Heredity_and_Environment_in_Schizophrenia,.3.pdf

by MK Belmonte - 2004 - Cited by 132

http://www.autismspeaks.org/docs/sciencedocs/d_200709_pinpointing_autism_unabridged.pdf

- Related articles

http://pdfs.journals.adisonline.com/drugs/2005/65110/Immunological_Aetiology_of_Major_Psychiatric.4.pdf

by RD Strous - Cited by 5

http://www.ima.org.il/imaj/ar05jan-12.pdf

A survey of related brain structures and neural processing .... (b) Mutation of the HLA-DQ6 gene, which reduces hypocretin secretion, is seen in .... 5) The glutamate theory maintains that schizophrenia is associated with a ... 5) Schizophrenia as a Developmental Disease. (a) Schizophrenia may begin prenatally ...

http://www.profhooper.info/PSB/PSBfiles/ChapterSummariesUnit4.pdf

fluential body of theory developed to describe ... THE SYNDROME OF SCHIZOPHRENIA found little basis for optimism. The neuro ...... several studies a consistent pattern of HLA ..... G. (1977). First rank symptoms of schizophrenia in Schneider-oriented ... Developmental. Psychology, 6487-96. THUDIcHiJM ...

http://bjp.rcpsych.org/cgi/reprint/136/5/421.pdf

monogenic theory of, testing. Ming T. Tsuang .... HLA antigens in schizophrenia: no differencebet ween patients with and without evidence of brain atrophy .... McCreadle, Robin G. The Nithsdale schizophrenia ..... Jefferson, James W. and Marshall, John R. Neuro ..... Developmental Disabilities :An annual review . ...

http://bjp.rcpsych.org/cgi/issue_pdf/backmatter_pdf/140/6.pdf

17 Jun 2009 ... theory has proposed a resolution: that genetic liability to schizophrenia has evolved as a secondary ...... Keller, M. C. & Miller, G. 2006 Resolving the paradox of .... neurodevelopmental origin of schizophrenia. Schizophr. ... R. M. 2001 Schizophrenia and HLA: a review. Schizophr. Res. 47, 1–12. ...

http://rspb.royalsocietypublishing.org/content/274/1627/2801.full.pdf

with adverse effects in the foetus (e.g. smoking), this theory remains .... neurodevelopmental model of schizophrenia most likely accounts for the majority .... schizophrenia loci in HLA regions. Outside the HLA region, the search for .... G, Sham P, He L. Rates of adult schizophrenia following prenatal ...

https://etd.sun.ac.za/bitstream/10019/1697/2/Koen, L.pdf

by O Almeida - Related articles

http://www.rcpsych.ac.uk/pdf/semOAP_ch10.pdf

Theory and background. Neurodevelopmental model of schizophrenia ..... Claridge G. Single indicator of risk for schizophrenia: probable fact or likely myth? Schizophr Bull. ..... uncovered a linkage with the HLA-A locus.64 In order to ...

http://www.dialogues-cns.org/brochures/09/pdf/09.pdf

found in schizophrenia not in depression. Overall the data ... in mice, overall a neurodevelopmental model of psychoses ..... with HLA-A10 genotype, a rather strong correlation (odds ... Weber F, Kron M, Büchele G, Mehrkens HH, Ludolph AC and .... 8 Smith RS: The macrophage theory of depression. Med Hypoth ...

http://iv.iiarjournals.org/content/21/5/917.full.pdf

13Maha I. Sh. Kawashti, 2Omnia R. Amin 3Nadia G. Rowehy ... schizophrenia (Kolvin, 1971). Soon recognized as a genetically-based biological ... genetic make up in class II HLA-DRB04 and .... aberrations consistent with neuro- developmental disorders such s autism ... proposed the opoid theory in autism, which ...

http://www.eji.eg.net/pdf/HQ2007-03680.pdf

negative regulation of G-protein signalling from receptors for neurotransmitters including ...... neurodevelopmental animal model of schizophrenia. Neurosci Biobeh Rev. 2005;. 29:913–947. .... for an association between schizophrenia and the HLA DQB1 gene locus. ...... Testing the monogenic theory of schizophrenia: ...

https://tspace.library.utoronto.ca/bitstream/1807/11281/1/Zai_Clement_C_200806_PhD_thesis.pdf

onset occurs at the end of a neurodevelopmental process lead- ..... nia and the human leukocyte antigen (HLA) A9 locus has been reported (71). Since the HLA loci are known ..... theories of schizophrenia implicate dysfunction of the frontal .... Clarke G. Prevention of depression in at-risk samples of adolescents. ...

http://ww1.cpa-apc.org:8080/publications/archives/cjp/2002/august/faraone.pdf

Neurotransmitter theories of schizophrenia have suggested multiple pathways, including glutamate and GABA alterations ...... The allele encoding glycine (G) is rarely carried against this haplotype ...... or family data: application to HLA in type 1 diabetes. ...... neurodevelopmental pathways in schizophrenia. ...

http://etd.library.pitt.edu/ETD/available/etd-07312008-153245/unrestricted/TalkowskiMEPhD08142008.pdf

by BH Shirts - 2006 - Related articles

http://etd.library.pitt.edu/ETD/available/etd-07272006-154050/unrestricted/ShirtsBrianH2006.pdf

native hypotheses for the genomic and developmental relation- ..... schizophrenia involve diametric alterations to aspects of neuro- ...

http://www.pnas.org/content/early/2009/11/30/0906080106.full.pdf

26 Jan 2010 ... native hypotheses for the genomic and developmental relation- ships between autism and schizophrenia: (i) .... DRD1, FOXP2, HLA-DRB1, and SHANK3, alternative alleles, .... Under-development of social phenotypes such as theory of ... schizophrenia involve diametric alterations to aspects of neuro- ...

http://www.pnas.org/content/107/suppl.1/1736.full.pdf