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sparingly soluble in strong acid (except insoluble in hydrochloric ... (pH 8.9) buffer was tested over the range 0.1–1.6 mol L–1. ...

http://www.springerlink.com/index/LCXAGGR2H88H55LG.pdf

Abstract—In pH 2.50 HCl-NaAc buffer solution, the reaction between telmisartan and congo red could form ion- .... telmisartan molecule, and they combined to 1 : 1, which .... product bigger than the substance solubility product. ...

http://www.springerlink.com/index/5H1528H177884222.pdf

CAS NUMBER: 144701-48-4 1 58-93-52. 1 Telmisartan. 2 Hydrochlorothiazide .... Water Solubility: Practically insoluble. Water Solubility: Slightly Soluble. Specific Gravity: ... Evaporation Rate: N/A. Evaporation Rate: N/A. pH: N/A. pH: ...

http://bi-msds.e3solutionsinc.com/Micardis HCT.pdf

biphenyl]-2-carboxylic acid. CAS TYPE: 1. GENERIC NAME: Telmisartan .... Evaporation Rate: N/A. Water Solubility: pH: N/A. 10. REACTIVITY DATA ...

http://bi-msds.e3solutionsinc.com/Micardis tabletsR2.pdf

It is practically insoluble in water and in the pH range of 3 to 9, sparingly soluble in strong acid (except insoluble in hydrochloric acid), and soluble in ...

http://tajapi.com/pdf/Telmisartan (Cas No 144701-48-4).pdf

10 Jan 2009 ... precise assessment of the very early phase of EAU is difficult, ... and increases soluble ICAM-1 release in vivo. ...

http://www.iovs.org/cgi/rapidpdf/iovs.08-2649v1.pdf

genic effects of telmisartan, an angiotensin II type 1 receptor ..... stage after the phase of hyperoxia-induced vaso-obliteration. .... vascular endothelial cells and increases soluble ICAM-1 release in vivo. Circulation. ...

http://www.iovs.org/cgi/reprint/46/3/1078.pdf

The incorporation of alkalizers in the SDs containing drug with pH dependent solubility like telmisartan could provide an alternative to enhancing ...

http://www.aapsj.org/abstracts/AM_2007/AAPS2007-002761.PDF

Telmisartan (TEL), a poorly water-soluble drug used for treatment of ... 37oC) in gastric fluid (pH 1.2) and intestinal fluid (pH 6.8) for 1 hr. ...

http://www.aapsj.org/abstracts/AM_2009/AAPS2009-003349.PDF

Ph. No. (02138) 222680. ABSTRACT: Solubility is an important physicochemical factor ... poorly soluble drug, Telmisartan. Solid dispersions were prepared using Polyvinyl .... Table 1. Formulation plan of Telmisartan solid dispersions ...

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by AB Patel - Related articles

/interstitial?url=http://sphinxsai.com/CTVOL3/ct=33.%20nehal%20shah%20CT%2023%20MAR.pdf

Telmisartan is characterised by a poor aqueous solubility and an ...... placebo run-in phase 363 patients were randomised to one of the following four treatments: 1. Telmisartan 40 mg once daily (response based titration to telmisartan ...

http://www.emea.europa.eu/humandocs/PDFs/EPAR/pritorplus/176202en6.pdf

placebo run-in phase 363 patients were randomised to one of the following four treatments: 1. Telmisartan 40 mg once daily (response based titration to ...

http://www.emea.europa.eu/humandocs/PDFs/EPAR/kinzalkomb/175702en6.pdf

Telmisartan (Fig. 1) is a lipophilic compound with a log P value of .... glucose, and 1.5 mM CaCl2 adjusted to pH 7.4) containing radiolabeled and ..... solubility of telmisartan in the incubation media. The uptake of ...

http://dmd.aspetjournals.org/content/34/7/1109.full.pdf

22 Sep 2006 ... with 5% not-fat dry milk prepared in D-PBS (pH 7.4) with 0.1 % Tween-20. After ..... Slightly soluble. Undetected. Telmisartan ...

http://dmd.aspetjournals.org/content/early/2006/09/22/dmd.106.012351.full.pdf

1. Computational Methods for. BCS/BDDCS. Peter W. Swaan, Ph.D. pswaan@rx.umaryland.edu ... Predict solubility and permeability separately .... Telmisartan. 86.71. 2.02. 7.12ą2.14. 3.53ą1.26. Cholecalciferol ...

http://www.aapspharmaceutica.com/meetings/files/90/31Swaan.pdf

sparingly soluble in water, freely soluble in Methanol and Acetonitrile. ... Telmisartan. Table 1- Result of recovery study of Telma-R tablet ..... Determination of telmisartan in rat tissues by in-tube solid-phase microextraction ...

http://www.ajpcr.com/Vol2Issue4/239.pdf

1. INDICATIONS AND USAGE. TWYNSTA (telmisartan/amlodipine) tablets are ..... insoluble in water and in the pH range of 3 to 9, sparingly soluble in strong ...

http://www.accessdata.fda.gov/drugsatfda_docs/label/2009/022401lbl.pdf

Telmisartan is chemically described as 4'-[(1,4'-dimethyl-2'-propyl[2,6'-bi-1H- ... in water and in the pH range of 3 to 9, sparingly soluble in strong acid ...

http://www.accessdata.fda.gov/drugsatfda_docs/label/1998/20850lbl.pdf

1. Vinayaka missions college of Pharmacy, Vinayaka mission University, Salem, Tamilnadu ... solubility. Reason Clinically, Telmisartan is a non- ..... 22) Tran PH, Tran HT,Lee B.J National Research Lab ,”For ...

/interstitial?url=http://ijprr.org/index_files/vol1no1/Design%20And%20Characterisation%20of%20Fast%20Dissolving%20Tablet%20of%20Telmisartan.pdf

SOLUBILITY IN WATER Insoluble (sparingly soluble in strong acid, soluble in strong base, pH 3 to 9). pH. VAPOR DENSITY ... Olmesartan, a specific angiotensin II type 1 antagonist, is used alone or with other antihypertensive ... Telmisartan. 144701-48-4. Candesartan cilexetil. 145040-37-5. Azilsartan. 147403-03-0 ...

http://chemicalland21.com/specialtychem/nd/OLMESARTAN MEDOXOMIL.pdf

angiotensin II antagonist telmisartan on gp130 expression .... HCl, pH 7.0, 1% sodium dodecyl sulfate (SDS), 2% 2- mercaptoethanol] were resolved by 8% ...

http://pdfs.journals.lww.com/jhypertension/2009/03000/Correlation_of_soluble_gp130_serum_concentrations.13.pdf

Soluble collagen was measured in the conditioned medium and non-soluble collagen in the cell layer. ... subtype 1 receptor antagonist, telmisartan, was kindly ... presence or absence of lisinopril, at pH 8.3 and at 378C, ...

http://pdfs.journals.lww.com/jhypertension/2004/01000/Collagen_production_in_cardiac_fibroblasts_during.31.pdf

telmisartan and ramipril, alone and in combination, in ... Phase. Headline. 1 700033539 Aliskiren. Amlodipine. Hydrochlorothiazide. Completed ...

http://www.p-d-r.com/ranking/Wolters Kluwer Health/Oktober/Hypertension October 2009.pdf

The only serious adverse events at least 1% more common on telmisartan than .... pH range of 3 to 9, sparingly soluble in strong acid (except insoluble in ...

http://www.bidocs.com/renetnt:/Prescribing+Information/PIs/Micardis+Tabs/MICARDIS20-40-80mg.PDF

Telmisartan, a non-peptide molecule, is chemically described as 4'-[(1,4'-dimethyl-2'-propyl[2,6'-bi-1H- ... It is practically insoluble in water and in the pH range of. 3 to 9, sparingly soluble in strong acid (except insoluble in ...

http://www.bidocs.com/renetnt:/Prescribing+Information/PIs/Micardis+HCT/MicardisHCT-US2.PDF

ARBs vary in lipid solubility and binding affinity to AT 1-receptors. ... of its high lipid solubility, PBS at pH 9.5 was used to dissolve telmisartan. ...

http://pt.wkhealth.com/pt/re/aha/fulltext.00005344-200805000-00006.pdf;jsessionid=LpsCpqVTWl15vz5LQzk7cC6y30L0GK7c1xpQSlXMRr74Bj83JPSX!1739349167!181195629!8091!-1!1260301474885

Telmisartan inhibits [beta]2-integrin MAC-1 expression in human T-lymphocytes. ... Pelat, Michel Ph.D. 1; Balligand, J-L M.D., Ph.D. 1 ...

http://pt.wkhealth.com/pt/re/pvd/fulltext.00043605-200207000-00030.pdf

24 Jun 2005 ... name for telmisartan is 4'-[(1,4'-dimethyl-2'-propyl[2 ... water, very slightly soluble in ethanol, slightly soluble in methanol and soluble in a .... Phase II clinical trial, 40, 80 and 120 mg of telmisartan were ...

http://www.drivetimeradio.com.au/pi/86/MICARDIS_PI.pdf

It is practically insoluble in water and in the pH range of 3 to 9, sparingly soluble in strong acid (except insoluble in hydrochloric ... telmisartan. The tablets contain the following inactive ingredients: ... Following oral administration, peak concentrations (Cmax) of telmisartan are reached in 0.5-1 hour after ...

http://medicaidprovider.hhs.mt.gov/pdf/micardisprescribinginformation.pdf

25 May 2006 ... Telmisartan is chemically described as 4'-[(1 ... It is practically insoluble in water and in the pH range of. 3 to 9, sparingly soluble in strong acid (except insoluble in hydrochloric acid), and soluble in strong base. ...

http://medicaidprovider.hhs.mt.gov/pdf/micardisrxinfo.pdf

found to be 0.5 to 1% in pH 1.2 buffer from both the pellets. .... phase solubility and in-vitro dissolution profile. ..... Physicochemical Characterization of Solid Dispersion of Telmisartan with Alkaliser by. Hot Melt Method ...

http://anvpublication.org/RJPDFT/RJPDFT_1_3_Abstract.pdf

25 Aug 2009 ... salt soluble collagen buffer (0.05M Tris buffer, pH 7.5, ..... telmisartan (Tel, 10 μM) was added 1 h before mesangial cells were treated ...

http://ecam.oxfordjournals.org/cgi/reprint/nep095v1.pdf

mM, pH 7.2 to rinse any residual blood out of the heart. The hearts were then perfused via the ... without telmisartan (10-7 M) or P-186 (10-7 M) for 1 ... measurement of soluble collagen. To each well, 1 ml of a solution containing ...

http://jra.sagepub.com/cgi/reprint/2/2/117.pdf

by M Iqbal - 2008 - Cited by 5

http://www.if-pan.krakow.pl/pjp/pdf/2008/3_382.pdf

The ONgoing Telmisartan Alone and in combination with Ramipril Global Endpoint ... plus diuretic combination after the acute phase of a stroke or transient ..... fresh fruits and vegetables, low fat dairy products, dietary and soluble ...

http://hypertension.ca/chep/wp-content/uploads/2009/07/2009-scientific-summary-final2.pdf

published rates of awareness, treatment and control of hypertension 1, 2. ... The ONgoing Telmisartan Alone and in combination with Ramipril Global Endpoint ... plus diuretic combination after the acute phase of a stroke or transient ..... in fresh fruits and vegetables, low fat dairy products, dietary and soluble ...

http://www.hypertension.ca/downloads/chep/ids/docs/PDF/Scientific_Summary_2009.pdf

cess of metabolism of lipid-soluble ... and morphine (see Table 1). Most drugs are metabolized via both Phase 1 and Phase 2 processes, but ... telmisartan losartan meperidine labetalol epirubicin. NSAIDs olanzapine. NSAIDs lorazepam ...

http://psy.psychiatryonline.org/cgi/reprint/43/1/77.pdf

drugs to increasingly water-soluble me- tabolites so that drugs can be inacti- vated and excreted in the bile or urine. P450 cytochromes (Phase 1) break off ...

http://psy.psychiatryonline.org/cgi/reprint/43/1/77.pdf?ck=nck

13 Oct 2005 ... with WRAIR: Expected to enter Phase 1 in early CY2006. •. Expanded contract with WRAIR .... Water Soluble. •. No anti-coagulant effect .... Telmisartan for hypertension, and Telmisartan/hydrochlorothiazide combo for ...

http://www.neurenpharma.com/ssl/cms/files_cms/NEU Market Update Oct2005.pdf

the decline in BP with angiotensin receptor subtype 1 (AT1) antagonism and vascular AT1 abundance were ... phase reactants other than CRP may contribute to the devel- ... telmisartan was administered for 7 days at 2 mg/kg per day in the ...... soluble guanylate cyclase activity in mice lacking the endothelial cell ...

http://circ.ahajournals.org/cgi/reprint/CIRCULATIONAHA.106.664854v1.pdf?referer=www.clickfind.com.au

3 Sep 2009 ... the decline in BP with angiotensin receptor subtype 1 (AT1) antagonism and vascular AT1 ... phase reactants other than CRP may contribute to the devel- ... telmisartan was administered for 7 days at 2 mg/kg per day in the ...... soluble guanylate cyclase activity in mice lacking the endothelial cell ...

http://circ.ahajournals.org/cgi/reprint/CIRCULATIONAHA.106.664854v1.pdf?ck=nck

02-01-00130 Telmisartan 40mg tab. 8000000. 02-01-00131 Telmisartan 80mg tab. 8000000 ...... 02-01-01355 phytomenadione tab or chewable tab or soluble tab 10mg ...... 02-01-05281 Buffer PBS powder sufficent to make 1 L ( PH 7. 2 ) ...

http://www.un.org/Depts/oip/dp/dp10/02-01.pdf

Telmisartan 40mg Tablet. 1274500. 02-01-00137. Telmisartan 80mg Tablet. 1283000 ...... Pilocarpine nitrate 2.0% w/v p.h Eur with purified water ...... shown on the pakage provided that all its ingredients are water soluble and leave no ...

http://www.un.org/Depts/oip/dp/dp12/02-01a.pdf

12 Nov 2008 ... Absorption phase should include 3-5 sampling time points ... Telmisartan. Ibandronate. Omeprazole (Fed). Rabeprazole. Risedronate. >50%. Lansoprazole (Fed, >75% ?) ..... BCS 1: High Solubility – High Permeability ...

http://www.pharsight.com/library/sign_in/Critical Path Opportunity for the Development of Generic Products.pdf

Mean peak concentrations of telmisartan are reached in 0.5-1 hour .... insoluble in water and in the pH range of 3 to 9, sparingly soluble in strong acid ( ...

http://www.boehringer-ingelheim.ca/en/Home/Human_Health/Our_Products/Product_Monographs/Micardis-pm.pdf

MICARDIS PLUS (80 mg telmisartan/12.5 mg hydrochlorothiazide) is ..... Adverse events at an incidence of 1% or more in patients treated with 80/12.5 mg ...... water and in the pH range of 3 to 9, sparingly soluble in strong acid (except ...

http://www.boehringer-ingelheim.ca/en/Home/Human_Health/Our_Products/Product_Monographs/Micardis-Plus-pm.pdf

was 15 days) were assigned to receive telmisartan (80mg daily) or a placebo. ... phase 1 month or more after onset. However, it may be started 1–2 ...

http://www.nature.com/hr/journal/v32/n1/pdf/hr200810a.pdf

For 12 h release, the ratio of drug with alone carbopol 934P (1:0.8) was .... interactions by using phase solubility studies, dissolution studies; XRD analysis, ..... of Orodispersible Tablets Containing Telmisartan Using Factorial ...

http://rjptonline.org/pdf/volume2_issue03_rjpt.pdf

to be responsible for over one third of all phase II ... drugs, and fat-soluble vitamins. UGT1A1 Genotyping and Irinotecan Toxicity .... telmisartan troglitazone diclofenac ketoconazole probenecid silibinin tacrolimus chrysin ...

http://www.mayomedicallaboratories.com/media/articles/communique/mc2831-0706.pdf